WHAT WE DO

MULTI-LEVEL APPROACHES TO DEFINE
ESSENTIAL MEMORY MOLECULES

In the Arey Lab, we take a discovery-based approach to uncover the molecular mechanisms of memory. How do we do that in the worm? Using newly developed genomics tools, we generate transcriptomic profiles in the context of behavioral training or genetic manipulation of the entire nervous system, individual neuron types, or even neuronal subcompartments. With these datasets, we can then use the wealth of genetic techniques in the worm to functionally test whether large sets of genes are required for the ability of animals to learn and remember using simple associative training assays. Once we have discovered new memory regulators, we take deep mechanistic dives and ask – Why are these genes important for memory? Can we target them to make memory better? To slow aging? These unbiased approaches have resulted in ever-evolving areas of inquiry in the lab.

Some of our ongoing projects in the lab include:

• Identifying “pro-memory” neuropeptide signals and their druggable receptors

• Newly discovered RNA binding proteins that control memory and neuronal function

• How environmental factors affect memory and cognitive aging trajectories

• Comparing memory transcriptomes and translatomes

• Sources of variation in individual memory performance

Supported by the following funding sources